Renal biopsy findings in hypertensive patients with proteinuria

Lancet. 1992 Dec 12;340(8833):1435-6. doi: 10.1016/0140-6736(92)92624-o.


27 patients with hypertension and persistent proteinuria were investigated by renal biopsy. The 13 patients without structural glomerular abnormalities were younger and had less proteinuria than the other 14, but otherwise the two groups had similar clinical features. 6 of the 14 had diffuse glomerular abnormalities; the other 8 had segmental sclerosing lesions, which were mainly in the hilum of the glomeruli, as seen in states of glomerular overload. Glomeruli in all groups were larger than those in normotensive people. It is possible that hypertension causes glomerular enlargement, proteinuria, and segmental glomerular lesions because of loss of functioning glomeruli due to ischaemia.

MeSH terms

  • Adult
  • Biopsy, Needle*
  • Female
  • Glomerulonephritis, IGA / complications
  • Glomerulonephritis, IGA / pathology
  • Glomerulonephritis, Membranous / etiology
  • Glomerulonephritis, Membranous / pathology
  • Glomerulosclerosis, Focal Segmental / etiology
  • Glomerulosclerosis, Focal Segmental / pathology
  • Humans
  • Hypertension / complications
  • Hypertension / pathology*
  • Hypertension, Renal / etiology
  • Kidney Glomerulus / pathology*
  • Male
  • Middle Aged
  • Proteinuria / etiology*
  • Retrospective Studies