Allele loss on chromosome 11p is associated with poor survival in ovarian cancer

Dis Markers. Mar-Apr 1992;10(2):95-9.


RFLP (restriction fragment length polymorphism) analysis in 46 ovarian tumour and paired blood samples shows that 33 per cent (5/15) of informative carcinomas had loss of heterozygosity (LOH) at 11p15.4 (Calcitonin locus) and 18% (4/22) had LOH at 11p15.5 (Ha-ras). No LOH was detected in five borderline and four benign ovarian tumours. Analysis of survival in the carcinoma group (37 patients) showed a significantly poorer survival in patients whose tumours showed LOH at either or both of these 11p loci (chi 2 = 7.771, p = 0.005). This suggests the presence of a tumour suppressor gene (tsg) on the short arm of chromosome 11 whose loss is associated with particularly aggressive disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Chromosomes, Human, Pair 11*
  • Female
  • Humans
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / mortality
  • Polymorphism, Restriction Fragment Length
  • Prognosis
  • Survival Analysis