The erbB-3 gene in human pancreatic cancer

J Pathol. 1992 Nov;168(3):269-73. doi: 10.1002/path.1711680305.


Abnormalities of the type 1 growth factor receptor family have been implicated in the pathogenesis of pancreatic cancer. There is evidence for a potential autocrine loop involving overexpression of the epidermal growth factor (EGF) receptor and its ligands, as well as overexpression of the erbB-2 receptor. A third member of this receptor family, erbB-3, has recently been recognized and found to be abnormally expressed in some types of human cancer. In this study we show that overexpression of the erbB-3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis. We found no evidence of amplification or rearrangement of the erbB-3 gene by Southern blot analysis of DNA from pancreatic cancer cells lines.

MeSH terms

  • Amino Acid Sequence
  • Blotting, Southern
  • Cell Line
  • Chronic Disease
  • ErbB Receptors / genetics
  • Gene Amplification
  • Gene Expression / genetics*
  • Gene Rearrangement
  • Humans
  • Immunohistochemistry
  • Molecular Sequence Data
  • Oncogene Proteins v-erbB
  • Pancreas / chemistry
  • Pancreatic Neoplasms / genetics*
  • Pancreatic Neoplasms / metabolism
  • Pancreatitis / genetics
  • Pancreatitis / metabolism
  • Proto-Oncogene Proteins / analysis
  • Proto-Oncogene Proteins / genetics*
  • Receptor, ErbB-3
  • Retroviridae Proteins, Oncogenic / genetics*


  • Oncogene Proteins v-erbB
  • Proto-Oncogene Proteins
  • Retroviridae Proteins, Oncogenic
  • ErbB Receptors
  • Receptor, ErbB-3