Effect of psychotropic drugs on histamine H2-receptors in rat isolated uterus

Methods Find Exp Clin Pharmacol. 1992 Jul-Aug;14(6):431-5.


The effects of the monoamine oxidase inhibitors iproniazid, nialamide and phenelzine, the neuroleptics haloperidol and thioridazine, and the benzodiazepines diazepam and clonazepam on histamine H2-receptors were assessed on rat isolated uterus. The monoamine oxidase inhibitors showed a slight non-competitive antihistamine H2 activity, while diazepam and clonazepam were devoid of any action. Haloperidol and thioridazine inhibited in a dose-dependent manner the tonic component of KCl induced contraction, while thioridazine under the same conditions exhibited a slight antihistamine H2 activity. These data show that the drugs tested are devoid of or elicited only a slight antihistamine H2 activity at high non-therapeutic concentrations.

MeSH terms

  • Animals
  • Anti-Anxiety Agents / pharmacology
  • Antipsychotic Agents / pharmacology
  • Benzodiazepines
  • Female
  • Histamine H2 Antagonists / pharmacology
  • In Vitro Techniques
  • Monoamine Oxidase Inhibitors / pharmacology
  • Potassium Chloride / pharmacology
  • Psychotropic Drugs / pharmacology*
  • Rats
  • Rats, Wistar
  • Receptors, Histamine H2 / drug effects*
  • Uterine Contraction / drug effects
  • Uterus / drug effects*


  • Anti-Anxiety Agents
  • Antipsychotic Agents
  • Histamine H2 Antagonists
  • Monoamine Oxidase Inhibitors
  • Psychotropic Drugs
  • Receptors, Histamine H2
  • Benzodiazepines
  • Potassium Chloride