Mechanisms of respiratory rhythm generation

Curr Opin Neurobiol. 1992 Dec;2(6):788-93. doi: 10.1016/0959-4388(92)90135-8.


In mammals, a three-phasic respiratory rhythm is generated by a network of various types of neurons in the lower brainstem. The cellular mechanisms of rhythmogenesis involve cooperative interactions between synaptic processes and specific membrane properties. The network seems to be driven by extrinsic sources in mature animals, whereas in the immature network pacemaker neurons might be involved.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Mammals / physiology
  • Models, Neurological
  • Neural Pathways / physiology
  • Neurotransmitter Agents / physiology
  • Periodicity*
  • Respiration / physiology*
  • Respiratory Center / physiology*
  • Synapses / physiology


  • Neurotransmitter Agents