Association between schizophrenia and homozygosity at the dopamine D3 receptor gene

J Med Genet. 1992 Dec;29(12):858-60. doi: 10.1136/jmg.29.12.858.

Abstract

Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Base Sequence
  • Chi-Square Distribution
  • Chromosomes, Human, Pair 3*
  • DNA / genetics
  • Deoxyribonucleases, Type II Site-Specific
  • Female
  • Gene Frequency
  • Homozygote
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Polymorphism, Restriction Fragment Length
  • Receptors, Dopamine / genetics*
  • Receptors, Dopamine D2*
  • Receptors, Dopamine D3
  • Risk Factors
  • Schizophrenia / genetics*

Substances

  • DRD3 protein, human
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • DNA
  • Deoxyribonucleases, Type II Site-Specific
  • TGGCCA-specific type II deoxyribonucleases