Pharmacology of antitumor agents from higher plants

Cancer Treat Rep. 1976 Aug;60(8):1127-39.

Abstract

Some pharmacologic properties of nine antitumor agents from higher plants are described. The agents are vincristine, vinblastine the epiodophyllotoxin derivatives VM-26 and VP-16-213, maytansine, bruceantin, thalicarpine, camptothecin, and lapachol. When sufficient information is available, the agents are discussed with regard to their antitumor activity, mechanism of action, pharmacologic disposition, structure-activity relationships, and toxicity.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Aporphines / pharmacology
  • Camptothecin / pharmacology
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / pathology
  • Chemical Phenomena
  • Chemistry
  • Etoposide / pharmacology
  • Humans
  • Leukemia L1210
  • Leukemia, Experimental / drug therapy
  • Leukemia, Lymphoid / drug therapy
  • Maytansine / pharmacology
  • Melanoma / drug therapy
  • Naphthoquinones / isolation & purification
  • Naphthoquinones / pharmacology
  • Nasopharyngeal Neoplasms / drug therapy
  • Nasopharyngeal Neoplasms / pathology
  • Neoplasms / drug therapy
  • Neoplasms, Experimental / drug therapy
  • Phenanthrenes / isolation & purification
  • Phenanthrenes / pharmacology
  • Structure-Activity Relationship
  • Teniposide / pharmacology
  • Vinblastine / pharmacology
  • Vincristine / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Aporphines
  • Naphthoquinones
  • Phenanthrenes
  • Maytansine
  • Vincristine
  • Vinblastine
  • Etoposide
  • Teniposide
  • Camptothecin