The genetics of multiple endocrine neoplasia (MEN)

Horm Res. 1992;38 Suppl 2:16-23. doi: 10.1159/000182587.


Multiple Endocrine Neoplasia (MEN) refers to the family of diseases characterized by hyperplasia and/or tumoral proliferation in various organs derived from the neural crest. MEN are transmitted in an autosomal dominant fashion in affected pedigrees with a high degree of penetrance. MEN 1 and MEN 2A/B loci have recently been mapped, respectively, to chromosomes 11 and 10 by linkage analysis using polymorphic DNA markers. These discoveries will lead (1) to a rapid understanding of the physiopathological pathway determining such syndromes and (2) to major clinical impact through the genetic screening.

Publication types

  • Review

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 10
  • Chromosomes, Human, Pair 11
  • Genetic Linkage
  • Genetic Testing
  • Humans
  • Multiple Endocrine Neoplasia / genetics*
  • Polymorphism, Restriction Fragment Length