Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats

Nat Genet. 1992 Jul;1(4):267-72. doi: 10.1038/ng0792-267.


We have evaluated the genes for angiotensin converting enzyme (ACE) and guanylyl cyclase A/atrial natriuretic peptide receptor (GCA) for genetic effects on blood pressure response to high salt diet. In F2 rats derived from Milan normotensive and Dahl salt-hypertension sensitive (S) rats, both ACE and GCA cosegregated with blood pressure, and rats that were homozygous for the S allele at both the ACE and GCA loci had inordinately high blood pressure. In F2 derived from Wistar Kyoto (WKY) and S rats, GCA revealed positive cosegregation with blood pressure, but ACE did not. We conclude that certain alleles at the GCA and ACE loci (or at loci closely linked to them) have a significant genetic impact on blood pressure response to high salt in specific rat strains.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Blood Pressure / genetics*
  • Crosses, Genetic
  • Female
  • Genetic Linkage
  • Genotype
  • Guanylate Cyclase / genetics*
  • Male
  • Molecular Sequence Data
  • Oligodeoxyribonucleotides
  • Peptidyl-Dipeptidase A / genetics*
  • Polymerase Chain Reaction / methods
  • Rats
  • Rats, Inbred BN
  • Rats, Inbred Lew
  • Rats, Inbred SHR
  • Rats, Inbred Strains / genetics*
  • Rats, Inbred WKY
  • Rats, Sprague-Dawley
  • Receptors, Atrial Natriuretic Factor / genetics*


  • Oligodeoxyribonucleotides
  • Peptidyl-Dipeptidase A
  • Guanylate Cyclase
  • Receptors, Atrial Natriuretic Factor