Molecular movements in oocyte patterning and pole cell differentiation

Bioessays. 1992 Aug;14(8):507-12. doi: 10.1002/bies.950140802.


Central to the differentiation and patterning of the Drosophila oocyte is the asymmetric intracellular localization of numerous mRNA and protein molecules involved in developmental signalling. Recent advances have identified some of the molecules mediating oocyte differentiation, specification of the anterior pole of the embryo, and determination of the embryonic germ line. This work is considered in the context of the classical model of the germ plasm as a cytoplasmic determinant for germ cell formation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Compartmentation
  • Cell Differentiation
  • Cell Polarity*
  • Cytoplasm / physiology
  • Drosophila melanogaster / cytology*
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics
  • Embryo, Nonmammalian / metabolism
  • Embryo, Nonmammalian / ultrastructure
  • Gene Expression Regulation, Developmental
  • Oocytes / physiology*
  • Oocytes / ultrastructure
  • Oogenesis