Reversion of L-lysine Inhibition of Penicillin G Biosynthesis by 6-oxopiperidine-2-carboxylic Acid in Penicillium Chrysogenum PQ-96

Appl Microbiol Biotechnol. 1990 Dec;34(3):397-8. doi: 10.1007/BF00170067.


6-Oxopiperidine-2-carboxylic acid (OCA; cyclic alpha-aminoadipic acid) reverses the L-lysine inhibition of penicillin G production by Penicillium chrysogenum PQ-96. The reaction probably depends on the recovery of L-alpha-aminoadipic acid for penicillin G production from OCA.

MeSH terms

  • 2-Aminoadipic Acid / pharmacology
  • Lysine / pharmacology*
  • Penicillin G / metabolism*
  • Penicillium chrysogenum / drug effects
  • Penicillium chrysogenum / metabolism*
  • Pipecolic Acids / pharmacology*


  • 6-oxopiperidine-2-carboxylic acid
  • Pipecolic Acids
  • 2-Aminoadipic Acid
  • Lysine
  • Penicillin G