Adiponectin: a regulator of energy homeostasis

Nutr Rev. 2003 Aug;61(8):290-2. doi: 10.1301/nr.2003.aug.290-292.


Adiponectin, a protein produced exclusively in adipose tissue, occurs in serum in relatively high concentration. Its concentration is decreased in obese and in type 2 diabetic humans. When administered to mice, it enhances insulin sensitivity and glucose tolerance, and appears to increase free fatty acid oxidation in muscle. Adiponectin is likely to be involved in the regulation of energy homeostasis.

Publication types

  • Review

MeSH terms

  • Adiponectin
  • Adipose Tissue / metabolism
  • Animals
  • Energy Metabolism / physiology*
  • Homeostasis / physiology
  • Humans
  • Intercellular Signaling Peptides and Proteins*
  • Mice
  • Obesity / metabolism
  • Proteins / metabolism
  • Proteins / physiology*


  • Adiponectin
  • Intercellular Signaling Peptides and Proteins
  • Proteins