Amyotrophic lateral sclerosis and primary lateral sclerosis: evidence-based diagnostic evaluation of the upper motor neuron

Neuroimaging Clin N Am. 2003 May;13(2):307-26. doi: 10.1016/s1052-5149(03)00018-2.


Magnetic resonance imaging and MR spectroscopy are important tools in the diagnostic evaluation of patients with suspected motor neuron disease. Further investigation is needed to determine and to compare the utility of various neuroimaging markers for diagnosis and disease progression [112]. Newer MR tools, such as diffusion tensor imaging, magnetization transfer imaging, and functional MR imaging, have substantial promise as scientific and clinical tools in this ongoing endeavor.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amyotrophic Lateral Sclerosis / diagnostic imaging*
  • Amyotrophic Lateral Sclerosis / pathology*
  • Evidence-Based Medicine*
  • Humans
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • Motor Neuron Disease / diagnostic imaging*
  • Motor Neuron Disease / pathology*
  • Motor Neurons / diagnostic imaging*
  • Motor Neurons / pathology*
  • Tomography, Emission-Computed
  • Tomography, Emission-Computed, Single-Photon
  • Tomography, X-Ray Computed