Secrets of a secretase: N-cadherin proteolysis regulates CBP function

Cell. 2003 Sep 5;114(5):533-5. doi: 10.1016/s0092-8674(03)00686-x.


Presenilin (PS-1) is part of the protease gamma-secretase that cleaves the membrane proteins APP and Notch. In this issue of Cell, Marambaud et al. report that PS-1 cleaves the cell adhesion molecule N-cadherin, releasing a C-terminal fragment that promotes degradation of the transcriptional coactivator CBP. Mutations in PS-1 associated with Alzheimer's disease interfere with CBP proteolysis, leading to abnormal transcription.

Publication types

  • Comment

MeSH terms

  • Animals
  • Binding Sites
  • Cadherins / metabolism
  • Cadherins / physiology*
  • Carrier Proteins / metabolism*
  • Cell Adhesion
  • Cell Membrane / metabolism
  • Cell Survival
  • Enzyme Activation
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Ligands
  • Mutation
  • Protein Structure, Tertiary
  • Transcription, Genetic
  • Transcriptional Activation


  • Cadherins
  • Carrier Proteins
  • Ligands
  • citrate-binding transport protein