CHRD, a novel domain in the BMP inhibitor chordin, is also found in microbial proteins

Trends Biochem Sci. 2003 Sep;28(9):470-3. doi: 10.1016/S0968-0004(03)00171-3.


CHRD (after SWISSPROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. Database searches have revealed several microbial homologues to this domain. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / genetics*
  • Bone Morphogenetic Proteins / antagonists & inhibitors
  • Glycoproteins / chemistry*
  • Glycoproteins / genetics*
  • Glycoproteins / pharmacology
  • Intercellular Signaling Peptides and Proteins*
  • Molecular Sequence Data
  • Protein Structure, Tertiary
  • Sequence Alignment
  • Sequence Homology, Amino Acid


  • Bacterial Proteins
  • Bone Morphogenetic Proteins
  • Glycoproteins
  • Intercellular Signaling Peptides and Proteins
  • chordin