Cyclosporine nephrotoxicity

Semin Nephrol. 2003 Sep;23(5):465-76. doi: 10.1016/s0270-9295(03)00090-1.


After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature analyzing the available data about the pathogenesis and mechanisms of acute and chronic cyclosporine-induced nephrotoxicity. A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Chronic Disease
  • Cyclosporine / adverse effects*
  • Drug-Related Side Effects and Adverse Reactions / etiology
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / immunology
  • Kidney Diseases / physiopathology*


  • Immunosuppressive Agents
  • Cyclosporine