Bioassay-guided isolation and identification of antifungal compounds from ginger

Phytother Res. 2003 Sep;17(8):897-902. doi: 10.1002/ptr.1335.

Abstract

A bioassay-guided isolation of antifungal compounds from an African land race of ginger, Zingiber officinale Roscoe, led to the identification of [6], [8] and [10]-gingerols and [6]-gingerdiol as the main antifungal principles. The compounds were active against 13 human pathogens at concentrations of <1 mg/mL. The gingerol content of the African land race was at least 3 x higher than that of typical commercial cultivars of ginger. Therefore, ginger extracts standardized on the basis of the identified compounds, could be considered as antifungal agents for practical therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology*
  • Antifungal Agents / therapeutic use
  • Dose-Response Relationship, Drug
  • Ginger*
  • Humans
  • Microbial Sensitivity Tests
  • Mitosporic Fungi / drug effects*
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Oils / administration & dosage
  • Plant Oils / chemistry
  • Plant Oils / pharmacology*
  • Plant Oils / therapeutic use
  • Plant Roots

Substances

  • Antifungal Agents
  • Plant Extracts
  • Plant Oils
  • Amphotericin B