Bacillus subtilis and its relatives: molecular biological and industrial workhorses

Trends Biotechnol. 1992 Jul;10(7):247-56. doi: 10.1016/0167-7799(92)90233-l.


The non-pathogenic bacterium Bacillus subtilis, since its first reported genetic transformation in 1959, has become a model system for the study of many aspects of the biochemistry, genetics and physiology of Gram-positive bacteria, and particularly of sporulation and associated metabolism. Extensive knowledge of the molecular biology of B. subtilis has led to the recent development of this bacterium as a host for the industrial production of heterologous proteins. Although difficulties have been encountered, these are being systematically addressed and overcome.

Publication types

  • Review

MeSH terms

  • Bacillus subtilis / genetics*
  • Bacillus subtilis / metabolism
  • Cloning, Molecular
  • Promoter Regions, Genetic
  • Protein Biosynthesis
  • Spores, Bacterial / physiology
  • Transformation, Bacterial