Receptor-based assays

Curr Opin Biotechnol. 1991 Feb;2(1):30-6. doi: 10.1016/0958-1669(91)90058-d.

Abstract

Receptor-based assays have benefitted from the newest advances in biotechnology and electronics in three main ways: genetically engineered cells expressing single receptor subtypes have been developed for many natural and synthetic ligands; assays have been designed which take advantage of a variety of signals triggered in cells by binding, or inhibition of binding, of ligands to surface-bound receptors; and radiolabelled ligand assays have been considerably improved and simplified by novel electronic devices.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Beta Particles
  • Filtration
  • Humans
  • Ligands
  • Phosphorylation
  • Receptors, Cell Surface / analysis*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / immunology
  • Tyrosine / metabolism

Substances

  • Ligands
  • Receptors, Cell Surface
  • Tyrosine