Abstract
Although the precise function of the retinoblastoma gene product, p110RB1, remains unknown, recent data suggest that it plays a role in the control of cellular proliferation by regulating transcription of genes required for a cell to enter or stay in a quiescent or G0 state, or for progression through the G1 phase of the cell cycle. However, it is difficult to rationalize the expression of p110RB1 in a wide range of tissues with the fact that mutations in the RB1 gene initiate cancers in a limited number of tissues.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alleles
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Animals
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Cell Cycle / genetics
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Cell Cycle / physiology*
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Cell Division
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Cell Transformation, Viral
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Child, Preschool
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Cyclins / genetics
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Cyclins / physiology
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Eye Neoplasms / genetics
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Fungal Proteins / physiology
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Genes, Retinoblastoma
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Humans
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Infant
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Mice
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Models, Genetic
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Oncogene Proteins, Viral / metabolism
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Oncogenes
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Oncogenic Viruses / physiology
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Organ Specificity
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Retinoblastoma / genetics
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Retinoblastoma Protein / genetics
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Retinoblastoma Protein / physiology*
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Schizosaccharomyces / genetics
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Schizosaccharomyces / physiology
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Species Specificity
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Transcription Factors / metabolism
Substances
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Cyclins
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Fungal Proteins
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Oncogene Proteins, Viral
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Retinoblastoma Protein
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Transcription Factors