Peripheral nerve injury triggers central sprouting of myelinated afferents

Nature. 1992 Jan 2;355(6355):75-8. doi: 10.1038/355075a0.


The central terminals of primary afferent neurons are topographically highly ordered in the spinal cord. Peripheral receptor sensitivity is reflected by dorsal horn laminar location: low-threshold mechanoreceptors terminate in laminae III and IV (refs 2, 3) and high-threshold nociceptors in laminae I, II and V (refs 4,5). Unmyelinated C fibres, most of which are nociceptors, terminate predominantly in lamina II (refs 5, 7). There is therefore an anatomical framework for the transfer of specific inputs to localized subsets of dorsal horn neurons. This specificity must contribute to the relationship between a low-intensity stimulus and an innocuous sensation and a noxious stimulus and pain. We now show that after peripheral nerve injury the central terminals of axotomized myelinated afferents, including the large A beta fibres, sprout into lamina II. This structural reorganization in the adult central nervous system may contribute to the development of the pain mediated by A-fibres that can follow nerve lesions in humans.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Afferent Pathways / physiology*
  • Animals
  • Axonal Transport
  • Axons / physiology
  • Axons / ultrastructure
  • Cholera Toxin
  • Horseradish Peroxidase
  • Nerve Fibers, Myelinated / physiology
  • Nerve Fibers, Myelinated / ultrastructure
  • Nerve Regeneration*
  • Sciatic Nerve / physiology*
  • Spinal Cord / physiology*
  • Sural Nerve / injuries*
  • Sural Nerve / physiology
  • Synapses / physiology
  • Synapses / ultrastructure
  • Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
  • Wheat Germ Agglutinins


  • Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
  • Wheat Germ Agglutinins
  • cholera toxin, B subunit-horseradish peroxidase
  • Cholera Toxin
  • Horseradish Peroxidase