Evidence for continuous stimulation of interleukin-6 production in Crohn's disease

Gastroenterology. 1992 Feb;102(2):514-9. doi: 10.1016/0016-5085(92)90098-j.


Increased serum concentrations of acute-phase proteins can be found in active inflammatory bowel disease. Because interleukin 6 (IL-6) is one of the main mediators of acute-phase protein synthesis by the liver, the serum concentrations of IL-6 and the acute-phase proteins C-reactive protein, alpha 1-antitrypsin, and alpha 1-acid glycoprotein were determined in 70 patients with Crohn's disease (CD) and 23 patients with ulcerative colitis (UC). Disease activities were determined by established clinical activity indices. Serum IL-6 concentrations were significantly (P less than 0.005) increased in patients with CD (mean +/- SEM, 6.8 +/- 0.9 U/mL) compared with patients with UC (mean, less than 4 U/mL) and healthy controls (mean, less than 4 U/mL). Of patients with CD, 68.5% had serum IL-6 concentrations of greater than or equal to 4 U/mL, compared with 21.7% of patients with UC and 0% of healthy controls. There was a tendency toward higher serum IL-6 concentrations in patients with active CD than in patients with inactive disease. However, these differences were not statistically significant. There was no correlation between IL-6 serum concentrations and clinical activity indices, possibly because of the short circulatory lifetime and rapid hepatic clearance of IL-6 from the portal venous blood. In contrast to serum IL-6, acute-phase proteins, which have a longer circulatory lifetime, were significantly correlated with clinical activity indices. Only the follow-up of individual patients with initially highly active disease showed a further increase in IL-6 levels during acute exacerbations of the inflammatory process. The results show that most patients with even moderately active CD have significantly increased serum concentrations of IL-6, most probably reflecting a continuous stimulation of IL-6-producing cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Acute-Phase Proteins / biosynthesis*
  • Adolescent
  • Adult
  • Aged
  • C-Reactive Protein / biosynthesis
  • Colitis, Ulcerative / blood
  • Crohn Disease / blood*
  • Female
  • Humans
  • Interleukin-6 / blood*
  • Liver / metabolism
  • Male
  • Middle Aged
  • Orosomucoid / biosynthesis
  • alpha 1-Antitrypsin / biosynthesis


  • Acute-Phase Proteins
  • Interleukin-6
  • Orosomucoid
  • alpha 1-Antitrypsin
  • C-Reactive Protein