IgG monoclonal proteins from patients with axonal peripheral neuropathies bind to different epitopes of the 68 kDa neurofilament protein

J Neuroimmunol. 1992 Feb;36(2-3):97-104. doi: 10.1016/0165-5728(92)90041-i.


We describe three patients with a sensorimotor axonal polyneuropathy and an IgG M-protein that binds to a 68 kDa axonal protein identified as the low molecular weight neurofilament protein (NF-L). The immunological studies revealed that the M-proteins have different target epitopes: one is phosphorylated and the other two are nonphosphorylated. One of the nonphosphorylated epitopes is common to other intermediate filaments, such as desmin and vimentin.

Publication types

  • Case Reports

MeSH terms

  • Axons / immunology*
  • Blood Proteins / immunology*
  • Epitopes / immunology*
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin G / immunology*
  • Immunoglobulins*
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neurofilament Proteins / immunology*
  • Peripheral Nervous System Diseases / immunology*
  • Peripheral Nervous System Diseases / pathology
  • Phosphorylation


  • Blood Proteins
  • Epitopes
  • Immunoglobulin G
  • Immunoglobulins
  • M-proteins (Myeloma)
  • Neurofilament Proteins