Anti-MAG IgM paraproteins from some patients with polyneuropathy associated with IgM paraproteinemia also react with sulfatide

J Neuroimmunol. 1992 Mar;37(1-2):85-92. doi: 10.1016/0165-5728(92)90158-h.

Abstract

Sera from five of 11 patients with neuropathy associated with IgM paraproteinemia (NAIgMPP) and reactivity against myelin-associated glycoprotein (MAG) also had elevated levels of IgM against sulfatide. Although three patients had anti-sulfatide IgM titers of less than or equal to 1:1000, two patients had titers of greater than or equal to 1:50,000. Absorption of patient serum with sulfatide revealed that anti-MAG IgM paraproteins in two patients with high titer anti-sulfatide IgM crossreacted with sulfatide. Our study is the first to show that some anti-MAG IgM paraproteins crossreact with sulfatide, a major acidic glycolipid of myelin. Moreover, some patients with NAIgMPP have polyclonal anti-sulfatide IgM in addition to anti-MAG IgM paraproteins. Therefore, sulfatide may be a target antigen in some patients with NAIgMPP.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antibodies / analysis
  • Globosides / immunology
  • Humans
  • Immunoglobulin M / immunology*
  • Myelin Proteins / immunology*
  • Myelin-Associated Glycoprotein
  • Nervous System Diseases / complications
  • Nervous System Diseases / immunology*
  • Paraproteinemias / complications*
  • Paraproteins / immunology*
  • Sulfoglycosphingolipids / immunology*

Substances

  • Antibodies
  • Globosides
  • Immunoglobulin M
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Paraproteins
  • Sulfoglycosphingolipids