Pharmacological manipulation of tissue cyclic AMP by inhibitors. Effects of phosphodiesterase inhibitors on the functions of platelets and vascular endothelial cells

Adv Second Messenger Phosphoprotein Res. 1992:25:215-27.

Authors

T Tani¹, K Sakurai, Y Kimura, T Ishikawa, H Hidaka

Affiliation

¹ Tokushima Research Institute, Otsuka Pharmaceutical Company, Ltd., Japan.

PMID: 1372812

No abstract available

MeSH terms

1-Methyl-3-isobutylxanthine / pharmacology
2',3'-Cyclic-Nucleotide Phosphodiesterases / analysis
2',3'-Cyclic-Nucleotide Phosphodiesterases / antagonists & inhibitors*
2',3'-Cyclic-Nucleotide Phosphodiesterases / isolation & purification
Blood Platelets / chemistry
Cells, Cultured
Cilostazol
Cyclic AMP / analysis*
Dose-Response Relationship, Drug
Endothelium, Vascular / cytology
Endothelium, Vascular / drug effects*
Humans
Platelet Aggregation / drug effects*
Tetrazoles / pharmacology*
Umbilical Cord
Vasodilator Agents / pharmacology

Substances

Tetrazoles
Vasodilator Agents
Cyclic AMP
2',3'-Cyclic-Nucleotide Phosphodiesterases
Cilostazol
1-Methyl-3-isobutylxanthine