alpha B-crystallin is present in reactive glia in Creutzfeldt-Jakob disease

Acta Neuropathol. 1992;83(3):324-7. doi: 10.1007/BF00296796.

Abstract

alpha-Crystallin is a major eye lens protein, composed of two types of subunits, alpha A and alpha B. The alpha A subunit is restricted to the lens, but alpha B-crystallin has recently also been detected in non-lenticular tissues, including the nervous system. With the use of a polyclonal antiserum directed against a synthetic C-terminal peptide of human alpha B-crystallin, the presence of alpha B-crystallin could be demonstrated immunohistochemically in astrocytes in the brains of patients with Creutzfeldt-Jakob disease (CJD). Most intensive localization was observed in the spongiotic tissue representing abundant progressively changed astrocytes in CJD. In age-matched control brains weak positive reaction was located in individual oligodendroglia cells and subpial astrocytes. Prominent increase of alpha B-crystallin in pathological glia in CJD may represent a response to stress.

MeSH terms

  • Amino Acid Sequence
  • Brain / metabolism
  • Brain / ultrastructure
  • Creutzfeldt-Jakob Syndrome / metabolism*
  • Creutzfeldt-Jakob Syndrome / pathology
  • Crystallins / chemistry
  • Crystallins / immunology
  • Crystallins / metabolism*
  • Epitopes
  • Humans
  • Immunohistochemistry / methods
  • Middle Aged
  • Molecular Sequence Data
  • Neuroglia / metabolism*
  • Staining and Labeling

Substances

  • Crystallins
  • Epitopes