Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis

Arthritis Rheum. 1992 May;35(5):550-6. doi: 10.1002/art.1780350509.


Objective: To compare the levels of biogenic amines in the cerebrospinal fluid (CSF) of primary fibromyalgia syndrome (PFS) patients with those in the CSF of controls.

Methods: Metabolites of serotonin, norepinephrine, and dopamine were identified in CSF, using high performance liquid chromatography with coulometric detection.

Results: CSF levels of metabolites from all 3 neurotransmitters were lower in PFS patients than in controls.

Conclusion: A low rate of turnover of several neurotransmitters supports the proposed hypothesis of a metabolic defect in PFS and suggests that the defect occurs at a neuroregulatory level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / cerebrospinal fluid*
  • Biogenic Amines / cerebrospinal fluid*
  • Female
  • Fibromyalgia / cerebrospinal fluid*
  • Humans
  • Hydroxyindoleacetic Acid / cerebrospinal fluid
  • Male
  • Middle Aged
  • Syndrome


  • Biogenic Amines
  • Hydroxyindoleacetic Acid