Glutamate-gated ion channels in the brain. Genetic mechanism for generating molecular and functional diversity

Arzneimittelforschung. 1992 Feb;42(2A):209-10.


L-glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system. Most cells are responsive to glutamate which activates cation channels with different pharmacological, kinetic, and ion permeability properties. These channels play important roles in neurotransmission, memory acquisition as well as acute and chronic disorders of the brain. The present report summarizes recent knowledge on AMPA (a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid) receptors which mediate fast synaptic neurotransmission.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain Chemistry / physiology
  • Glutamates / physiology*
  • Glutamic Acid
  • Humans
  • Ion Channel Gating / genetics
  • Ion Channel Gating / physiology*
  • Ion Channels / genetics
  • Ion Channels / physiology*
  • Neurotransmitter Agents / physiology*
  • Receptors, AMPA
  • Receptors, Neurotransmitter / physiology


  • Glutamates
  • Ion Channels
  • Neurotransmitter Agents
  • Receptors, AMPA
  • Receptors, Neurotransmitter
  • Glutamic Acid