Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds

J Nat Prod. 1992 Mar;55(3):340-6. doi: 10.1021/np50081a010.

Abstract

Salaspermic acid [1], an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells, was isolated from the roots of Tripterygium wilfordii for the first time. The structure of 1 derived from spectral data was established unequivocally by an X-ray analysis of crystals of the monohydrate. A structure-activity correlation of 1 with ten related compounds indicated that the acetal linkage in ring A and the carboxyl group in ring E of 1 may be required for the anti-HIV activity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antiviral Agents / pharmacology*
  • Cells, Cultured
  • HIV Reverse Transcriptase
  • HIV-1 / drug effects*
  • HIV-1 / enzymology
  • Humans
  • Lymphocytes / drug effects
  • Lymphocytes / microbiology
  • Molecular Conformation
  • Plants, Medicinal / chemistry*
  • Reverse Transcriptase Inhibitors
  • Structure-Activity Relationship
  • Triterpenes / chemistry
  • Triterpenes / pharmacology*
  • X-Ray Diffraction

Substances

  • Antiviral Agents
  • Reverse Transcriptase Inhibitors
  • Triterpenes
  • salaspermic acid
  • HIV Reverse Transcriptase