Abstract
Several recently discovered mammalian cell adhesion proteins recognize and bind to sialic acid-containing ligands. Reports concerning the molecular specificities of these interactions have been intriguing but somewhat confusing, partly because of pitfalls in methodology or interpretation. Nevertheless, these protein-carbohydrate recognition phenomena are important in the normal biology of blood cells and in the pathophysiology of many diseases.
MeSH terms
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Animals
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Carbohydrate Sequence
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Cell Adhesion Molecules / metabolism
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Humans
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Lectins / metabolism*
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Molecular Sequence Data
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Oligosaccharides / chemistry
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Oligosaccharides / metabolism
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P-Selectin
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Platelet Membrane Glycoproteins / metabolism*
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Sialic Acid Binding Immunoglobulin-like Lectins
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Sialic Acids / metabolism
Substances
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Cell Adhesion Molecules
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Lectins
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Oligosaccharides
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P-Selectin
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Platelet Membrane Glycoproteins
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Sialic Acid Binding Immunoglobulin-like Lectins
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Sialic Acids