Granulocyte colony-stimulating factor-producing large cell undifferentiated carcinoma of the lung

Intern Med. 1992 Feb;31(2):277-80. doi: 10.2169/internalmedicine.31.277.


We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Animals
  • Carcinoma, Non-Small-Cell Lung / metabolism*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Female
  • Granulocyte Colony-Stimulating Factor / biosynthesis*
  • Granulocytes / pathology
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms / metabolism*
  • Lung Neoplasms / pathology
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation


  • Granulocyte Colony-Stimulating Factor