Demonstration of mismatch negativity in the monkey

Electroencephalogr Clin Neurophysiol. 1992 Jul;83(1):87-90. doi: 10.1016/0013-4694(92)90137-7.


In humans, deviant auditory stimuli elicit an event-related potential (ERP) component, termed "mismatch negativity" (MMN), that reflects the operation of a cortical detector of infrequent stimulus change. Epidural auditory ERPs were recorded from 3 cynomolgous monkeys in response to soft and loud clicks. "Oddball" loud or soft stimuli elicited a long-duration frontocentral negativity, peaking at approximately 85 msec, that was superimposed upon cortically generated obligatory ERP components. These data suggest that monkeys might serve as a heuristically valuable system in which to study the neurochemical and neuroanatomical substrates of early context-dependent ERP generation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acoustic Stimulation
  • Animals
  • Brain / physiology*
  • Electroencephalography
  • Evoked Potentials / physiology*
  • Macaca fascicularis
  • Male
  • Reaction Time / physiology