Bleomycin-detectable iron in the plasma of premature and full-term neonates

FEBS Lett. 1992 Jun 1;303(2-3):210-2. doi: 10.1016/0014-5793(92)80521-h.


The bleomycin assay measures non-transferrin-bound iron, able to catalyze free radical reactions, in human plasma. No bleomycin-detectable iron is present in plasma from healthy adults. However, plasma from 3/15 premature babies was positive in this assay. Plasma from 52 apparently-healthy term babies was analyzed and 11 were positive in the bleomycin assay. Hence not only some premature but also some full-term apparently-healthy babies may be at risk of severe oxidative damage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bleomycin
  • Humans
  • Hydrogen-Ion Concentration
  • Infant, Newborn / blood*
  • Infant, Premature / blood*
  • Iron / blood*


  • Bleomycin
  • Iron