Clonal aberrations of chromosomes X, Y, 7 and 10 in normal kidney tissue of patients with renal cell tumors

Genes Chromosomes Cancer. 1992 Jan;4(1):75-7. doi: 10.1002/gcc.2870040110.

Abstract

By means of G-banding techniques, chromosome aberrations were studied in short-term cultures of normal renal parenchymal cells from 45 patients with renal cell carcinoma. Clonal chromosomal aberrations were detected in 29 patients; loss of the Y chromosome as well as trisomy X, 5, 7, 9, 10, 12, and 18 was found. Chromosomes 7 and 10 were involved preferentially. Results of fluorescence in situ hybridization with chromosome 7- and 10-specific DNA probes on non-cultured normal kidney cells suggested that the aberrations developed in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Carcinoma, Renal Cell / pathology*
  • Cells, Cultured
  • Chromosome Aberrations*
  • Chromosome Banding
  • Chromosomes, Human, Pair 10 / ultrastructure
  • Chromosomes, Human, Pair 7 / ultrastructure
  • Clone Cells / pathology*
  • DNA Probes
  • Female
  • Fluorescent Dyes
  • Humans
  • Kidney / pathology*
  • Kidney Neoplasms / pathology*
  • Male
  • Mosaicism
  • Nucleic Acid Hybridization
  • X Chromosome / ultrastructure
  • Y Chromosome / ultrastructure

Substances

  • DNA Probes
  • Fluorescent Dyes