Suppression of experimental autoimmune encephalomyelitis by gallium nitrate

J Neuroimmunol. 1992 Jul;39(1-2):175-81. doi: 10.1016/0165-5728(92)90186-o.


We examined the effect of gallium (Ga) nitrate on the development of the development of experimental autoimmune encephalomyelitis (EAE). Weekly subcutaneous injections of 10-30 mg/kg prevented clinical signs as well as histopathological changes of EAE. The optimal timing of a single injection of Ga was 6 days after induction of EAE, with amelioration also apparent following a single injection on day 3 or 9 but not day 12. Ga administered in vivo suppressed myelin basic protein (MBP) and purified protein derivative-specific lymphocyte proliferative responses in vitro. Addition of Ga to MBP-specific T lymphocyte line cultures at various times after initiation of culture revealed that Ga exerts an effect at an early stage of cellular activation.

MeSH terms

  • Animals
  • Autoimmune Diseases / physiopathology*
  • Cell Division / drug effects
  • Cell Line
  • Concanavalin A / pharmacology
  • Encephalomyelitis, Autoimmune, Experimental / physiopathology*
  • Gallium / pharmacology*
  • Lymphocyte Activation / drug effects
  • Male
  • Myelin Basic Protein / pharmacology
  • Rats
  • Rats, Inbred Lew
  • T-Lymphocytes / cytology
  • T-Lymphocytes / drug effects
  • Tuberculin


  • Myelin Basic Protein
  • Tuberculin
  • Concanavalin A
  • Gallium
  • gallium nitrate