Autoantibodies in polymyositis

Rheum Dis Clin North Am. 1992 May;18(2):455-82.


A group of autoantibodies have been identified that are found almost exclusively in patients with polymyositis and dermatomyositis (myositis-specific antibodies). Most have been associated with characteristic clinical subgroups. Five of the myositis-specific antibodies are directed at aminoacyl-tRNA synthetases and have been associated with a similar clinical syndrome marked by myositis, interstitial lung disease, arthritis, and Raynaud's phenomenon (antisynthetase syndrome). Myositis-specific antibodies can help with patient diagnosis, subgroup classification, and possible prognosis. Their role in the pathogenesis of myositis remains to be defined, but their production is genetically influenced and appears to be linked to fundamental etiologic factors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acyl-tRNA Synthetases / immunology
  • Amino Acyl-tRNA Synthetases / metabolism
  • Antibody Specificity
  • Antigens / immunology
  • Autoantibodies* / immunology
  • Cell Nucleus / immunology
  • Cytoplasm / immunology
  • Epitopes
  • Humans
  • Myositis / immunology*


  • Antigens
  • Autoantibodies
  • Epitopes
  • Amino Acyl-tRNA Synthetases