An 'anatomical cascade hypothesis' for Alzheimer's disease

Trends Neurosci. 1992 Jun;15(6):200-1. doi: 10.1016/0166-2236(92)90033-5.


The molecular mechanisms of the cytopathology of Alzheimer's disease are very rapidly being elucidated. However, the factors that restrict the effects of this disease to specific neuroanatomical systems are less well understood. In this brief article a possible hypothesis is outlined to explain this apparent specific localization.

MeSH terms

  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology*
  • Amyloid beta-Peptides / metabolism
  • Humans
  • Organ Specificity


  • Amyloid beta-Peptides