Nitric oxide: a pathogenetic factor in autoimmunity

Immunol Today. 1992 May;13(5):157-60. doi: 10.1016/0167-5699(92)90118-Q.

Abstract

Nitric oxide (NO) has been identified recently as a multifunctional mediator, produced by, and acting on, most cells of the body. Besides its function as endothelium-derived relaxing factor, as a neurotransmitter and as an immune defence molecule, evidence is accumulating that NO participates in inflammatory- and autoimmune-mediated tissue destruction. Modulation of NO synthesis and action represents a new approach to the treatment of inflammatory and autoimmune conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Oxidoreductases / antagonists & inhibitors
  • Amino Acid Oxidoreductases / classification
  • Amino Acid Oxidoreductases / metabolism
  • Animals
  • Arginine / metabolism
  • Arginine / pharmacology
  • Autoimmunity / physiology*
  • Calcium / physiology
  • Cell Adhesion
  • Cell Death
  • Diabetes Mellitus, Experimental / immunology
  • Diabetes Mellitus, Experimental / pathology
  • Diabetes Mellitus, Type 1 / physiopathology
  • Enzyme Induction
  • Humans
  • Inflammation / physiopathology
  • Islets of Langerhans / pathology
  • Isoenzymes / metabolism
  • Macrophage Activation
  • Mice
  • Neutrophils / metabolism
  • Nitric Oxide / immunology*
  • Nitric Oxide / toxicity
  • Nitric Oxide Synthase

Substances

  • Isoenzymes
  • Nitric Oxide
  • Arginine
  • Nitric Oxide Synthase
  • Amino Acid Oxidoreductases
  • Calcium