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Case Reports
, 167 (2), 509-11

Congenital Deficiency of Alpha-Fetoprotein

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Case Reports

Congenital Deficiency of Alpha-Fetoprotein

F Greenberg et al. Am J Obstet Gynecol.

Abstract

Although alpha-fetoprotein may play a role in fetal immune function or in maintenance of osmotic pressure, its exact function is unknown. We report two infants documented to have congenital deficiency of alpha-fetoprotein. One infant had cord blood levels less than 0.5 ng/ml. The second infant had a neonatal level of 120 ng/ml, which is about 2% of the usual concentration for a term newborn. These infants document the existence of congenital deficiency of serum alpha-fetoprotein. Because it is homologous to albumin, congenital deficiency of alpha-fetoprotein may be analogous to analbuminemia, a benign genetic trait.

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