A plasminogen-related gene is expressed in cancer cells

Biochem Biophys Res Commun. 1992 Jul 31;186(2):1108-14. doi: 10.1016/0006-291x(92)90861-e.

Abstract

The breakdown of blood clots requires the fibrinolytic action of the serine proteinase plasmin, a two-chain polypeptide derived posttranslationally from its precursor zymogen, plasminogen. While investigating plasminogen gene expression in human extrahepatic tissues, a cDNA sequence was obtained which closely resembled the plasminogen cDNA, yet appeared to represent a distinct gene product. This sequence, which represents the transcript of the recently characterized plasminogen-related gene B, encodes a putative polypeptide of Mr 8800 and is expressed most prominently in malignant cancer cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Amino Acid Sequence
  • Base Sequence
  • Bone Neoplasms / enzymology
  • Bone Neoplasms / genetics*
  • Bone Neoplasms / pathology
  • Breast Neoplasms / enzymology
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • DNA, Neoplasm / genetics
  • DNA, Neoplasm / isolation & purification
  • Female
  • Gene Expression
  • Humans
  • Liver / enzymology
  • Lung Neoplasms / enzymology
  • Lung Neoplasms / genetics
  • Lung Neoplasms / secondary*
  • Molecular Sequence Data
  • Neoplasm Staging
  • Osteosarcoma / enzymology
  • Osteosarcoma / genetics*
  • Osteosarcoma / pathology
  • Plasminogen / genetics*
  • Polymerase Chain Reaction / methods
  • RNA / genetics
  • RNA / isolation & purification
  • Restriction Mapping

Substances

  • DNA, Neoplasm
  • RNA
  • Plasminogen

Associated data

  • GENBANK/D10916
  • GENBANK/D10917
  • GENBANK/D10918
  • GENBANK/D10919
  • GENBANK/D10920
  • GENBANK/M93143
  • GENBANK/S39218
  • GENBANK/S39219
  • GENBANK/S39220
  • GENBANK/S39221