Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosis

Kidney Int. 1992 Apr;41(4):951-5. doi: 10.1038/ki.1992.145.


Frozen sections of renal biopsy specimens from eight patients with primary focal segmental glomerulosclerosis (FSGS) and 10 patients with membranous nephropathy (MN) were stained in immuno-peroxidase with the intercellular adhesion molecule-1 (ICAM-1) monoclonal antibody (MoAb), CL203.4. ICAM-1 was expressed by mesangial cells in six patients with FSGS. On the other hand, ICAM-1 was not detected in mesangial cells in patients with MN or in the non-affected portion of tumoral kidneys used to control normal renal expression of ICAM-1. De novo mesangial expression of ICAM-1 in FSGS suggests that sclerosis results from an inflammatory process, possibly associated with local release of cytokines.

MeSH terms

  • Antibodies, Monoclonal
  • Cell Adhesion Molecules / metabolism*
  • Glomerular Mesangium / metabolism*
  • Glomerulosclerosis, Focal Segmental / metabolism*
  • Humans
  • Intercellular Adhesion Molecule-1
  • Kidney / metabolism
  • Reference Values
  • Staining and Labeling
  • Tissue Distribution


  • Antibodies, Monoclonal
  • Cell Adhesion Molecules
  • Intercellular Adhesion Molecule-1