Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages

Biochem Biophys Res Commun. 1992 Sep 16;187(2):1123-7. doi: 10.1016/0006-291x(92)91313-f.


Prostaglandin H synthase is a key enzyme in the formation of prostaglandins and thromboxane from arachidonic acid. The recent cloning of a second prostaglandin H synthase gene, prostaglandin H synthase-2, which is distinct from the classic prostaglandin H synthase-1 gene, may dramatically alter our concept of how cells regulate prostanoid formation. We have recently shown that the enhanced production of prostanoids by lipopolysaccharide-primed alveolar macrophages involves the induction of a novel prostaglandin H synthase (J. Biol. Chem., (1992), 267, 14547-14550). We report here that the novel PGH synthase induced by lipopolysaccharide in alveolar macrophages is prostaglandin H synthase-2.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blotting, Western
  • Enzyme Induction
  • Epitopes / immunology
  • Immunosorbent Techniques
  • Lipopolysaccharides*
  • Macrophages, Alveolar / enzymology*
  • Molecular Weight
  • Nucleic Acid Hybridization
  • Prostaglandin-Endoperoxide Synthases / biosynthesis*
  • Prostaglandin-Endoperoxide Synthases / genetics
  • Prostaglandin-Endoperoxide Synthases / immunology
  • RNA, Messenger / biosynthesis
  • Rabbits
  • Transfection


  • Epitopes
  • Lipopolysaccharides
  • RNA, Messenger
  • Prostaglandin-Endoperoxide Synthases