Trisomy 5 and trisomy 7 are nonrandom aberrations in pigmented villonodular synovitis: confirmation of trisomy 7 in uncultured cells

Genes Chromosomes Cancer. 1992 Apr;4(3):264-6. doi: 10.1002/gcc.2870040312.


Pigmented villonodular synovitis (PVNS) is a proliferative lesion of disputed genesis. Recently, we reported trisomy 7 in short-term cultures of 1 PVNS. In the present report, we describe another specimen of PVNS in which 9 of 26 (35 percent) metaphase cells demonstrated trisomy 7 when analyzed after 3-15 days of tissue culture. In situ hybridization analysis, with a biotinylated probe to chromosome 7 alpha-satellite DNA, revealed trisomy 7 in 53 of 200 uncultured cells from this PVNS sample. Our findings indicate that trisomy 7 is a nonrandom aberration that arises in vivo in PVNS.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosomes, Human, Pair 5*
  • Chromosomes, Human, Pair 7*
  • Culture Techniques
  • Female
  • Humans
  • Middle Aged
  • Mosaicism
  • Nucleic Acid Hybridization
  • Synovitis, Pigmented Villonodular / genetics*
  • Trisomy*