Abstract
In rat peritoneal mast cells induced by anti-immunoglobulin E, ciwujianosides D1 (1) and C1 (2) from Acanthopanax senticosus (ciwujia) strongly inhibited histamine release in a concentration-dependent manner. The inhibitory effect of 1 was approximately 6800 times stronger than that of disodium cromoglycate.
MeSH terms
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Animals
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Antibodies, Anti-Idiotypic / immunology*
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Cells, Cultured
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Histamine Release / drug effects*
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Immunoglobulin E / immunology*
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Male
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Mast Cells / drug effects
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Mast Cells / metabolism*
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Oleanolic Acid* / analogs & derivatives*
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Peritoneal Cavity / cytology
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Plant Extracts / pharmacology
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Plants, Medicinal / chemistry*
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Rats
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Rats, Wistar
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Saponins / pharmacology*
Substances
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Antibodies, Anti-Idiotypic
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Plant Extracts
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Saponins
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ciwujianoside C1
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ciwujianoside D1
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Immunoglobulin E
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Oleanolic Acid