Avidity of antibodies in SLE: relation to severity of renal involvement

Arthritis Rheum. Jan-Feb 1977;20(1):23-9. doi: 10.1002/art.1780200104.

Abstract

The avidity of antibodies to DNA in the sera of 8 patients with SLE was determined by saturation analysis and Scatchard plots. Five of the patients had severe lupus nephritis; the other 3 had relatively mild or no kidney disease. The Scatchard plots revealed components with high relative avidity in the patients with severe nephritis (K values 4.4-10.4 X 10(5) M-1 for nDNA), compared with the patients who had mild or no kidney disease (K values 0.3-1.8 X 10(5) M-1 for nDNA). Avidity measurements may be helpful in the evaluation and treatment of patients with SLE.

MeSH terms

  • Affinity Labels
  • Autoantibodies / analysis*
  • Binding Sites, Antibody
  • DNA / immunology
  • Glomerulonephritis / immunology
  • Humans
  • Immune Complex Diseases / immunology
  • Kidney / immunology*
  • Lupus Erythematosus, Systemic / immunology*
  • Prognosis

Substances

  • Affinity Labels
  • Autoantibodies
  • DNA