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Clinical Trial
. 1992 Nov;56(5):863-7.
doi: 10.1093/ajcn/56.5.863.

Eating Behavior and Adherence to Dietary Prescriptions in Obese Adult Subjects Treated With 5-hydroxytryptophan

Affiliations
Clinical Trial

Eating Behavior and Adherence to Dietary Prescriptions in Obese Adult Subjects Treated With 5-hydroxytryptophan

C Cangiano et al. Am J Clin Nutr. .

Abstract

Previous observations have shown that oral administration of 5-hydroxytryptophan (5-HTP) without dietary prescriptions causes anorexia, decreased food intake, and weight loss in obese subjects. To confirm these data over a longer period of observation and to verify whether adherence to dietary restriction could be improved by 5-HTP, 20 obese patients were randomly assigned to receive either 5-HTP (900 mg/d) or a placebo. The study was double-blinded and was for two consecutive 6-wk periods. No diet was prescribed during the first period, a 5040-kJ/d diet was recommended for the second. Significant weight loss was observed in 5-HTP-treated patients during both periods. A reduction in carbohydrate intake and a consistent presence of early satiety were also found. These findings together with the good tolerance observed suggest that 5-HTP may be safely used to treat obesity.

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