Changes in anti-U1 RNA antibody levels correlate with disease activity in patients with systemic lupus erythematosus overlap syndrome

Arthritis Rheum. 1992 Oct;35(10):1202-10. doi: 10.1002/art.1780351013.


Objective: To evaluate correlations between changes in anti-U1 RNA antibody levels and disease activity in 9 patients with systemic lupus erythematosus (SLE) overlap syndrome who were prospectively followed up for at least 3 years.

Methods: Anti-U1 RNA antibody levels were measured quantitatively, using a nitrocellulose filter binding assay. Disease activity was measured with a validated SLE activity index.

Results: All 9 major disease exacerbations were associated with peaks in anti-U1 RNA antibody level.

Conclusion: These results seem to indicate that measuring anti-U1 RNA antibody levels can be useful for monitoring disease activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Autoantibodies / metabolism*
  • Epitopes / immunology
  • Female
  • Follow-Up Studies
  • Humans
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / immunology*
  • Male
  • Middle Aged
  • Mixed Connective Tissue Disease / complications
  • Mixed Connective Tissue Disease / immunology
  • Prospective Studies
  • RNA / immunology*
  • Ribonucleoprotein, U1 Small Nuclear / genetics
  • Ribonucleoprotein, U1 Small Nuclear / immunology*
  • Syndrome


  • Autoantibodies
  • Epitopes
  • Ribonucleoprotein, U1 Small Nuclear
  • RNA