High prevalence of Clostridium difficile diarrhoea during intensive chemotherapy for disseminated germ cell cancer

H Nielsen; G Daugaard; M Tvede; B Bruun

doi:10.1038/bjc.1992.334

High prevalence of Clostridium difficile diarrhoea during intensive chemotherapy for disseminated germ cell cancer

Br J Cancer. 1992 Oct;66(4):666-7. doi: 10.1038/bjc.1992.334.

Authors

H Nielsen¹, G Daugaard, M Tvede, B Bruun

Affiliation

¹ Department of Clinical Microbiology, Rigshopitalet, Copenhagen, Denmark.

Abstract

A prospective, consecutive study of the aetiology of treatment-associated diarrhoea was conducted in 25 patients with disseminated germ cell cancer treated with intensive chemotherapy. Clostridium difficile was isolated in 45% of the diarrhoea episodes, which makes this species the most important bacterial pathogen in the development of clinically significant diarrhoea in this group of immunocompromised patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Bleomycin / administration & dosage
Bleomycin / adverse effects
Cisplatin / administration & dosage
Cisplatin / adverse effects
Clostridioides difficile / isolation & purification*
Diarrhea / drug therapy
Diarrhea / microbiology*
Etoposide / administration & dosage
Etoposide / adverse effects
Humans
Immunocompromised Host*
Neoplasms, Germ Cell and Embryonal / drug therapy*
Prevalence
Prospective Studies

Substances

Bleomycin
Etoposide
Cisplatin