The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci

Genomics. 1992 Jul;13(3):654-7. doi: 10.1016/0888-7543(92)90137-h.


The IL-1 receptor antagonist (IL-1RN) is a protein that binds to IL-1 receptors and inhibits the binding of IL-1 alpha and IL-1 beta. As a consequence, the biological activity of these two cytokines is neutralized in physiological and pathophysiological immune and inflammatory responses. In this study, using a panel of somatic rodent-human cell hybrids, we show that the gene for the human interleukin-1 receptor antagonist (IL1RN) maps to the long arm of chromosome 2. Previously, we described a length variation polymorphism within the second intron of the IL-1RN gene (Steinkasserer et al., 1991, Nucleic Acids Res. 19: 5095). Segregation of this, together with an IL-1 alpha polymorphism, was followed in a panel of five CEPH families. Linkage analysis permitted the mapping of the IL-1RN gene to band q14-q21 in the region for the IL-1 alpha and IL-1 beta loci. This study supports the view that an early gene duplication event resulted in the creation of an interleukin-1 gene family.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 2*
  • Genetic Linkage
  • Humans
  • Hybrid Cells
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1 / genetics*
  • Multigene Family
  • Polymerase Chain Reaction
  • Proteins / genetics*
  • Receptors, Immunologic / antagonists & inhibitors*
  • Receptors, Interleukin-1
  • Sialoglycoproteins*


  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1
  • Proteins
  • Receptors, Immunologic
  • Receptors, Interleukin-1
  • Sialoglycoproteins