Human hallucinogen interactions with drugs affecting serotonergic neurotransmission

Neuropsychopharmacology. 1992 Nov;7(3):241-3.


The absence of relevant human research studies of hallucinogenic drugs has not curtailed their unsupervised use. Two cases are presented that suggest decreased sensitivity to the serotonergic hallucinogens psilocybin and LSD induced by drugs with effects on serotonergic neurotransmission, allopurinol and fluoxetine. These reports suggest that hallucinogens' effects in humans are mediated by serotonergic receptors.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Drug Interactions
  • Hallucinogens / pharmacology*
  • Humans
  • Male
  • Receptors, Serotonin / drug effects*


  • Hallucinogens
  • Receptors, Serotonin